Isabella (Penelope Cruz) is a beautiful Brazilian enchantress who runs a successful restaurant with her husband, Nino. However, when Isabella finds out that Nino has been cheating on her she heads for San Francisco to pursue her dream of a culinary career on her own. She moves in with her childhood friend, cross-dresser Monica, and is soon given the opportunity to host her own TV show - an offer she cannot refuse. Meanwhile back in Brazil, Nino has decided to travel northwards in a bid to win back his wife’s love.
